Expression of thioredoxins and glutaredoxins in human hepatocellular carcinoma: correlation to cell proliferation, tumor size and metabolic syndrome.
Identifieur interne : 000583 ( Main/Exploration ); précédent : 000582; suivant : 000584Expression of thioredoxins and glutaredoxins in human hepatocellular carcinoma: correlation to cell proliferation, tumor size and metabolic syndrome.
Auteurs : A. Mollbrink [Suède] ; R. Jawad [Suède] ; A. Vlamis-Gardikas [Grèce] ; P. Edenvik [Suède] ; B. Isaksson [Suède] ; O. Danielsson [Suède] ; P. St L [Suède] ; A P Fernandes [Suède]Source :
- International journal of immunopathology and pharmacology [ 0394-6320 ]
Descripteurs français
- KwdFr :
- ARN messager (analyse), Adulte d'âge moyen (MeSH), Carcinome hépatocellulaire (anatomopathologie), Carcinome hépatocellulaire (enzymologie), Carcinome hépatocellulaire (génétique), Charge tumorale (MeSH), Facteurs de risque (MeSH), Femelle (MeSH), Glutarédoxines (analyse), Glutarédoxines (génétique), Humains (MeSH), Immunohistochimie (MeSH), Inclusion en paraffine (MeSH), Marqueurs biologiques tumoraux (analyse), Marqueurs biologiques tumoraux (génétique), Mâle (MeSH), Prolifération cellulaire (MeSH), Pronostic (MeSH), Protéines de transport (analyse), Protéines mitochondriales (analyse), Sujet âgé (MeSH), Syndrome métabolique X (enzymologie), Thiorédoxines (analyse), Thiorédoxines (génétique), Tumeurs colorectales (anatomopathologie), Tumeurs du foie (anatomopathologie), Tumeurs du foie (enzymologie), Tumeurs du foie (génétique), Tumeurs du foie (secondaire), Études cas-témoins (MeSH).
- MESH :
- analyse : ARN messager, Glutarédoxines, Marqueurs biologiques tumoraux, Protéines de transport, Protéines mitochondriales, Thiorédoxines.
- anatomopathologie : Carcinome hépatocellulaire, Tumeurs colorectales, Tumeurs du foie.
- enzymologie : Carcinome hépatocellulaire, Syndrome métabolique X, Tumeurs du foie.
- génétique : Carcinome hépatocellulaire, Glutarédoxines, Marqueurs biologiques tumoraux, Thiorédoxines, Tumeurs du foie.
- secondaire : Tumeurs du foie.
- Adulte d'âge moyen, Charge tumorale, Facteurs de risque, Femelle, Humains, Immunohistochimie, Inclusion en paraffine, Mâle, Prolifération cellulaire, Pronostic, Sujet âgé, Études cas-témoins.
English descriptors
- KwdEn :
- Aged (MeSH), Biomarkers, Tumor (analysis), Biomarkers, Tumor (genetics), Carcinoma, Hepatocellular (enzymology), Carcinoma, Hepatocellular (genetics), Carcinoma, Hepatocellular (pathology), Carrier Proteins (analysis), Case-Control Studies (MeSH), Cell Proliferation (MeSH), Colorectal Neoplasms (pathology), Female (MeSH), Glutaredoxins (analysis), Glutaredoxins (genetics), Humans (MeSH), Immunohistochemistry (MeSH), Liver Neoplasms (enzymology), Liver Neoplasms (genetics), Liver Neoplasms (pathology), Liver Neoplasms (secondary), Male (MeSH), Metabolic Syndrome (enzymology), Middle Aged (MeSH), Mitochondrial Proteins (analysis), Paraffin Embedding (MeSH), Prognosis (MeSH), RNA, Messenger (analysis), Risk Factors (MeSH), Thioredoxins (analysis), Thioredoxins (genetics), Tumor Burden (MeSH).
- MESH :
- chemical , analysis : Biomarkers, Tumor, Carrier Proteins, Glutaredoxins, Mitochondrial Proteins, RNA, Messenger, Thioredoxins.
- chemical , genetics : Biomarkers, Tumor, Glutaredoxins, Thioredoxins.
- enzymology : Carcinoma, Hepatocellular, Liver Neoplasms, Metabolic Syndrome.
- genetics : Carcinoma, Hepatocellular, Liver Neoplasms.
- pathology : Carcinoma, Hepatocellular, Colorectal Neoplasms, Liver Neoplasms.
- secondary : Liver Neoplasms.
- Aged, Case-Control Studies, Cell Proliferation, Female, Humans, Immunohistochemistry, Male, Middle Aged, Paraffin Embedding, Prognosis, Risk Factors, Tumor Burden.
Abstract
Thioredoxins (Trx) and glutaredoxins (Grx) are thiol oxidoreductases that are ubiquitously expressed, and are involved in several biological processes. The expression of thioredoxins and glutaredoxins is induced in many neoplasms, and correlates with prognosis in gallbladder and colorectal carcinoma. The aim of the present study was to examine the expression pattern of these proteins (redoxins) in hepatocellular carcinoma (HCC) and to correlate their levels with clinical features. Paraffin-embedded tissues from 25 patients resected for HCC and 15 patients resected for colorectal carcinoma (CRC) liver metastases were analyzed with immunohistochemistry. Our results showed that Trx1, Trx2 and Grx5 were upregulated in HCCs as compared to the respective surrounding liver. In comparison, almost all redoxins were upregulated in CRC liver metastases, with Trx1 and Grx3 being significantly more increased in the CRC liver metastases than in the primary HCC tumors. In HCC, Trx1 correlated significantly with cell proliferation, and with a trend towards increased levels with micro-vascular invasion, while expression of Trx2 decreased with tumor size. Trx1 levels were lower in tumors of males, smokers, and patients with high alcohol consumption. Grx2 levels were significantly higher in patients with metabolic syndrome. In conclusion, this study illustrates specific correlations of individual redoxins to clinical features of HCC, and implicates the redoxins in the pathogenesis of HCC.
DOI: 10.1177/039463201402700204
PubMed: 25004829
Affiliations:
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Jawad</name><affiliation wicri:level="3"><nlm:affiliation>Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Vlamis Gardikas, A" sort="Vlamis Gardikas, A" uniqKey="Vlamis Gardikas A" first="A" last="Vlamis-Gardikas">A. 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Isaksson</name><affiliation wicri:level="3"><nlm:affiliation>Division of Gastroenterology and Hepatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Division of Gastroenterology and Hepatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Danielsson, O" sort="Danielsson, O" uniqKey="Danielsson O" first="O" last="Danielsson">O. Danielsson</name><affiliation wicri:level="3"><nlm:affiliation>Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="St L, P" sort="St L, P" uniqKey="St L P" first="P" last="St L">P. St L</name><affiliation wicri:level="3"><nlm:affiliation>Division of Gastroenterology and Hepatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Division of Gastroenterology and Hepatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Fernandes, A P" sort="Fernandes, A P" uniqKey="Fernandes A" first="A P" last="Fernandes">A P Fernandes</name><affiliation wicri:level="3"><nlm:affiliation>Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author></analytic><series><title level="j">International journal of immunopathology and pharmacology</title><idno type="ISSN">0394-6320</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged (MeSH)</term><term>Biomarkers, Tumor (analysis)</term><term>Biomarkers, Tumor (genetics)</term><term>Carcinoma, Hepatocellular (enzymology)</term><term>Carcinoma, Hepatocellular (genetics)</term><term>Carcinoma, Hepatocellular (pathology)</term><term>Carrier Proteins (analysis)</term><term>Case-Control Studies (MeSH)</term><term>Cell Proliferation (MeSH)</term><term>Colorectal Neoplasms (pathology)</term><term>Female (MeSH)</term><term>Glutaredoxins (analysis)</term><term>Glutaredoxins (genetics)</term><term>Humans (MeSH)</term><term>Immunohistochemistry (MeSH)</term><term>Liver Neoplasms (enzymology)</term><term>Liver Neoplasms (genetics)</term><term>Liver Neoplasms (pathology)</term><term>Liver Neoplasms (secondary)</term><term>Male (MeSH)</term><term>Metabolic Syndrome (enzymology)</term><term>Middle Aged (MeSH)</term><term>Mitochondrial Proteins (analysis)</term><term>Paraffin Embedding (MeSH)</term><term>Prognosis (MeSH)</term><term>RNA, Messenger (analysis)</term><term>Risk Factors (MeSH)</term><term>Thioredoxins (analysis)</term><term>Thioredoxins (genetics)</term><term>Tumor Burden (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN messager (analyse)</term><term>Adulte d'âge moyen (MeSH)</term><term>Carcinome hépatocellulaire (anatomopathologie)</term><term>Carcinome hépatocellulaire (enzymologie)</term><term>Carcinome hépatocellulaire (génétique)</term><term>Charge tumorale (MeSH)</term><term>Facteurs de risque (MeSH)</term><term>Femelle (MeSH)</term><term>Glutarédoxines (analyse)</term><term>Glutarédoxines (génétique)</term><term>Humains (MeSH)</term><term>Immunohistochimie (MeSH)</term><term>Inclusion en paraffine (MeSH)</term><term>Marqueurs biologiques tumoraux (analyse)</term><term>Marqueurs biologiques tumoraux (génétique)</term><term>Mâle (MeSH)</term><term>Prolifération cellulaire (MeSH)</term><term>Pronostic (MeSH)</term><term>Protéines de transport (analyse)</term><term>Protéines mitochondriales (analyse)</term><term>Sujet âgé (MeSH)</term><term>Syndrome métabolique X (enzymologie)</term><term>Thiorédoxines (analyse)</term><term>Thiorédoxines (génétique)</term><term>Tumeurs colorectales (anatomopathologie)</term><term>Tumeurs du foie (anatomopathologie)</term><term>Tumeurs du foie (enzymologie)</term><term>Tumeurs du foie (génétique)</term><term>Tumeurs du foie (secondaire)</term><term>Études cas-témoins (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Biomarkers, Tumor</term><term>Carrier Proteins</term><term>Glutaredoxins</term><term>Mitochondrial Proteins</term><term>RNA, Messenger</term><term>Thioredoxins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Biomarkers, Tumor</term><term>Glutaredoxins</term><term>Thioredoxins</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>ARN messager</term><term>Glutarédoxines</term><term>Marqueurs biologiques tumoraux</term><term>Protéines de transport</term><term>Protéines mitochondriales</term><term>Thiorédoxines</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Carcinome hépatocellulaire</term><term>Tumeurs colorectales</term><term>Tumeurs du foie</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Carcinome hépatocellulaire</term><term>Syndrome métabolique X</term><term>Tumeurs du foie</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Carcinoma, Hepatocellular</term><term>Liver Neoplasms</term><term>Metabolic Syndrome</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Carcinoma, Hepatocellular</term><term>Liver Neoplasms</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Carcinome hépatocellulaire</term><term>Glutarédoxines</term><term>Marqueurs biologiques tumoraux</term><term>Thiorédoxines</term><term>Tumeurs du foie</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Carcinoma, Hepatocellular</term><term>Colorectal Neoplasms</term><term>Liver Neoplasms</term></keywords><keywords scheme="MESH" qualifier="secondaire" xml:lang="fr"><term>Tumeurs du foie</term></keywords><keywords scheme="MESH" qualifier="secondary" xml:lang="en"><term>Liver Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Case-Control Studies</term><term>Cell Proliferation</term><term>Female</term><term>Humans</term><term>Immunohistochemistry</term><term>Male</term><term>Middle Aged</term><term>Paraffin Embedding</term><term>Prognosis</term><term>Risk Factors</term><term>Tumor Burden</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Charge tumorale</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Immunohistochimie</term><term>Inclusion en paraffine</term><term>Mâle</term><term>Prolifération cellulaire</term><term>Pronostic</term><term>Sujet âgé</term><term>Études cas-témoins</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Thioredoxins (Trx) and glutaredoxins (Grx) are thiol oxidoreductases that are ubiquitously expressed, and are involved in several biological processes. The expression of thioredoxins and glutaredoxins is induced in many neoplasms, and correlates with prognosis in gallbladder and colorectal carcinoma. The aim of the present study was to examine the expression pattern of these proteins (redoxins) in hepatocellular carcinoma (HCC) and to correlate their levels with clinical features. Paraffin-embedded tissues from 25 patients resected for HCC and 15 patients resected for colorectal carcinoma (CRC) liver metastases were analyzed with immunohistochemistry. Our results showed that Trx1, Trx2 and Grx5 were upregulated in HCCs as compared to the respective surrounding liver. In comparison, almost all redoxins were upregulated in CRC liver metastases, with Trx1 and Grx3 being significantly more increased in the CRC liver metastases than in the primary HCC tumors. In HCC, Trx1 correlated significantly with cell proliferation, and with a trend towards increased levels with micro-vascular invasion, while expression of Trx2 decreased with tumor size. Trx1 levels were lower in tumors of males, smokers, and patients with high alcohol consumption. Grx2 levels were significantly higher in patients with metabolic syndrome. In conclusion, this study illustrates specific correlations of individual redoxins to clinical features of HCC, and implicates the redoxins in the pathogenesis of HCC. </div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25004829</PMID><DateCompleted><Year>2014</Year><Month>08</Month><Day>11</Day></DateCompleted><DateRevised><Year>2017</Year><Month>11</Month><Day>16</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0394-6320</ISSN><JournalIssue CitedMedium="Print"><Volume>27</Volume><Issue>2</Issue><PubDate><MedlineDate>2014 Apr-Jun</MedlineDate></PubDate></JournalIssue><Title>International journal of immunopathology and pharmacology</Title><ISOAbbreviation>Int J Immunopathol Pharmacol</ISOAbbreviation></Journal><ArticleTitle>Expression of thioredoxins and glutaredoxins in human hepatocellular carcinoma: correlation to cell proliferation, tumor size and metabolic syndrome.</ArticleTitle><Pagination><MedlinePgn>169-83</MedlinePgn></Pagination><Abstract><AbstractText>Thioredoxins (Trx) and glutaredoxins (Grx) are thiol oxidoreductases that are ubiquitously expressed, and are involved in several biological processes. The expression of thioredoxins and glutaredoxins is induced in many neoplasms, and correlates with prognosis in gallbladder and colorectal carcinoma. The aim of the present study was to examine the expression pattern of these proteins (redoxins) in hepatocellular carcinoma (HCC) and to correlate their levels with clinical features. Paraffin-embedded tissues from 25 patients resected for HCC and 15 patients resected for colorectal carcinoma (CRC) liver metastases were analyzed with immunohistochemistry. Our results showed that Trx1, Trx2 and Grx5 were upregulated in HCCs as compared to the respective surrounding liver. In comparison, almost all redoxins were upregulated in CRC liver metastases, with Trx1 and Grx3 being significantly more increased in the CRC liver metastases than in the primary HCC tumors. In HCC, Trx1 correlated significantly with cell proliferation, and with a trend towards increased levels with micro-vascular invasion, while expression of Trx2 decreased with tumor size. Trx1 levels were lower in tumors of males, smokers, and patients with high alcohol consumption. Grx2 levels were significantly higher in patients with metabolic syndrome. In conclusion, this study illustrates specific correlations of individual redoxins to clinical features of HCC, and implicates the redoxins in the pathogenesis of HCC. </AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mollbrink</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Division of Gastroenterology and Hepatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jawad</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vlamis-Gardikas</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Chemistry, University of Patras, Rion, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Edenvik</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Division of Gastroenterology and Hepatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Isaksson</LastName><ForeName>B</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Division of Gastroenterology and Hepatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Danielsson</LastName><ForeName>O</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stål</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Division of Gastroenterology and Hepatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fernandes</LastName><ForeName>A P</ForeName><Initials>AP</Initials><AffiliationInfo><Affiliation>Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Int J Immunopathol Pharmacol</MedlineTA><NlmUniqueID>8911335</NlmUniqueID><ISSNLinking>0394-6320</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014408">Biomarkers, Tumor</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D002352">Carrier Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C516008">GLRX2 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C404105">GLRX3 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C516011">GLRX5 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D054477">Glutaredoxins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D024101">Mitochondrial Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012333">RNA, Messenger</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C491203">TXN protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C467002">TXN2 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>52500-60-4</RegistryNumber><NameOfSubstance UI="D013879">Thioredoxins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014408" MajorTopicYN="N">Biomarkers, Tumor</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006528" MajorTopicYN="N">Carcinoma, Hepatocellular</DescriptorName><QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002352" MajorTopicYN="N">Carrier Proteins</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D049109" MajorTopicYN="Y">Cell Proliferation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015179" MajorTopicYN="N">Colorectal Neoplasms</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D054477" MajorTopicYN="N">Glutaredoxins</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007150" MajorTopicYN="N">Immunohistochemistry</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008113" MajorTopicYN="N">Liver Neoplasms</DescriptorName><QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName><QualifierName UI="Q000556" MajorTopicYN="N">secondary</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D024821" MajorTopicYN="N">Metabolic Syndrome</DescriptorName><QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D024101" MajorTopicYN="N">Mitochondrial Proteins</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016612" MajorTopicYN="N">Paraffin Embedding</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011379" MajorTopicYN="N">Prognosis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012333" MajorTopicYN="N">RNA, Messenger</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013879" MajorTopicYN="N">Thioredoxins</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D047368" MajorTopicYN="N">Tumor Burden</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>7</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>7</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>8</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25004829</ArticleId><ArticleId IdType="pii">4</ArticleId><ArticleId IdType="doi">10.1177/039463201402700204</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Grèce</li><li>Suède</li></country><region><li>Svealand</li></region><settlement><li>Stockholm</li></settlement></list><tree><country name="Suède"><region name="Svealand"><name sortKey="Mollbrink, A" sort="Mollbrink, A" uniqKey="Mollbrink A" first="A" last="Mollbrink">A. Mollbrink</name></region><name sortKey="Danielsson, O" sort="Danielsson, O" uniqKey="Danielsson O" first="O" last="Danielsson">O. Danielsson</name><name sortKey="Edenvik, P" sort="Edenvik, P" uniqKey="Edenvik P" first="P" last="Edenvik">P. Edenvik</name><name sortKey="Fernandes, A P" sort="Fernandes, A P" uniqKey="Fernandes A" first="A P" last="Fernandes">A P Fernandes</name><name sortKey="Isaksson, B" sort="Isaksson, B" uniqKey="Isaksson B" first="B" last="Isaksson">B. Isaksson</name><name sortKey="Jawad, R" sort="Jawad, R" uniqKey="Jawad R" first="R" last="Jawad">R. Jawad</name><name sortKey="St L, P" sort="St L, P" uniqKey="St L P" first="P" last="St L">P. St L</name></country><country name="Grèce"><noRegion><name sortKey="Vlamis Gardikas, A" sort="Vlamis Gardikas, A" uniqKey="Vlamis Gardikas A" first="A" last="Vlamis-Gardikas">A. Vlamis-Gardikas</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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